These includes well-documented pathways in CRC including the cell adhesion molecule, Hedgehog signaling, phosphatidylinositol 3′-kinase (PI3K)-Akt signaling, focal adhesion, pathways in cancer, basal cell carcinoma, colorectal cancer, Wnt signaling, Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling, transcriptional misregulation in cancer and mitogen-activated protein kinase (MAPK) signaling pathway. The gene discussed is WNK2; the disease is colorectal carcinoma.