Of the 27 hypermethylated genes with low gene expression, 18 were related to CRC including GSTM2, ZNF655, MYH11, HHIP, RSPO3, RNF152, CAV1, SFRP2, JAM2, SPG20, TMEFF2, SST, SLIT2, SCNN1B, ADAMST1, GLI3, CKB and BMP3 (19,30–38). The gene discussed is MYH11; the disease is colorectal carcinoma.