Of the 27 hypermethylated genes with low gene expression, 18 were related to CRC including GSTM2, ZNF655, MYH11, HHIP, RSPO3, RNF152, CAV1, SFRP2, JAM2, SPG20, TMEFF2, SST, SLIT2, SCNN1B, ADAMST1, GLI3, CKB and BMP3 (19,30–38). This evidence concerns the gene RNF152 and colorectal carcinoma.