In conclusion, the in vitro transwell invasion assay capacity of gastric cancer cells is enhanced under hypoxic conditions when HIF-1α expression is increased by activating the Wnt/β-catenin signaling pathway, subsequently inducing the expression of uPA and MMP-7, which act on the extracellular matrix, promoting cell invasion and the development of gastric cancer. Here, HIF1A is linked to gastric cancer.