ERBB2 and neoplasm: Thus, while a strategy such as withholding HER2-targeted therapies in patients with negatively prognostic tumor-level genetic alterations (e.g., PI3K mutations) is impractical [22], augmenting the depressed anti-HER2 Th1 immunity in non-pCR patients may be more feasible as an adjunct to existing HER2-targeted therapies to improve clinical outcomes.