CD28 and stroke disorder: Regarding the relationship between immune-inflammatory variables and severity markers (see Table 3), we have observed no significant relationship between peripheral frequency of CD4+ cells and chosen stroke severity indicators, whereas we observed a significant relationship between peripheral frequency of CD4+CD28− cells and SSS (β = −0.049; P = 0.046) and NIHSS (β = −0.460; P = 0.042) scores.