Despite a similar incidence of joint involvement in both groups, all ACPA-positive ASS patients suffered from arthritis versus 14 patients (41%) in ACPA-negative ASS patients, resulting in an odds ratio (OR) for arthritis of 49.5, 95% confidence interval (CI) 2.8–891, and P < 0.0001 (Table 1). The gene discussed is PRTN3; the disease is arthritic joint disease.