Together with the fact that DNMT3B expression was higher in FLT3-ITD-positive vs. FLT3-ITD-negative patients (not shown), this points to FLT3-ITD induced upregulation of DNMT3B or upregulation of DNMT3B by another yet uncharacterized pathway is a poor prognostic factor in normal karyotype AML. The gene discussed is DNMT3B; the disease is acute myeloid leukemia.