Recently, we have described genetic mutations and epigenetic alterations (“epimutations”) in the gene encoding for DNA methyltransferase 3A (DNMT3A) [4] which affect DNMT3A isoform expression and are associated with an inferior prognosis in AML, clustering together with FLT3-ITD mutations but not with AML1-ETO translocations. This evidence concerns the gene RUNX1T1 and acute myeloid leukemia.