The ROC curve comparing HCC patients with patients with any other condition (including healthy controls, HBV or HCV carriers and patients with cirrhosis) showed that GDF15 was superior to AFP in diagnosing HCC in this cohort, with an AUROC of 0.84 (95% CI 0.8091 to 0.8761), a sensitivity of 86.79% and a specificity of 72.75%. The gene discussed is AFP; the disease is Cirrhosis.