Several inflammatory mediators secreted from adipose tissue, including interleukin-1α (IL-1α), IL-1β, IL-6, IL-10, tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP1) and prostaglandin E2, have been shown to be involved in joint diseases [12–14]. The gene discussed is CCL2; the disease is arthropathy.