STZ rats have normal [3H]CGP12177 uptake early after the induction of hyperglycemia, but binding of [3H]CGP12177 to cardiac β-AR becomes reduced by up to 50% after 6 to 8 weeks of sustained hyperglycemia HHHHhjhsdjfbsdlvhbasekjfvbadsrjvkbasrejfbw[14,15]. This evidence concerns the gene ADRB2 and Hyperglycemia.