However, there are no large sample multi-center studies, no systematic review and meta-analysis on interleukin-8 for diagnosis of neonatal sepsis, therefore, we conducted this systematic review and meta-analysis to assess the validity of IL-8 test for early diagnosis neonatal sepsis, and systematically and quantitatively evaluate all published studies about the diagnostic value of IL-8 test for NS. The gene discussed is CXCL8; the disease is Neonatal sepsis.