At the local site of infection, multiplex cytokine analysis of lung samples revealed no significant differences in IFN-γ, TNF-α and IL-2 secretion between TV Ad35+ and TV Ad26+ groups and their respective controls (IFN-γ: p = 0.35; TNF-α: p = 0.98; IL-2: p = 0.09; ANOVA) (Fig 7b). The gene discussed is TNF; the disease is infection.