LGR5 and esophageal adenocarcinoma: Barrett’s esophagus (BE) is a metaplastic conversion to intestinal columnar epithelium and is associated with an increased risk of adenocarcinoma, similar to that observed with gastric IM.[12] Notably, human BE lesions exhibit an upregulation of LGR5 expression when compared to normal squamous epithelium, and is suggestive of the presence of a LGR5+ stem cells in BE.[13]