This finding is consistent with a previous report showing that LGR5 expression was significantly elevated in BE, and that population is the likely cell-of-origin for this metaplasia.[13] More recently, LGR5+ cells were identified in the middle of Barrett’s glands by in situ hybridization and are suggested to act as stem cells, as they exhibit both gastric and intestinal differentiation.[34] We also found LGR5+ cells at the areas between gastric and metaplastic glands in BE, which correspond to the middle of Barrett’s glands. The gene discussed is LGR5; the disease is Barrett esophagus.