Parientin showed cytotoxicity against HL-60 cells, Jurkat, HCT-116 p53−/− (colon carcinoma submanifold without p53) and A2780, with IC50 values of 93.5, 181.6, 197.5 and 197.9 μg∙mL−1, respectively, and gyrophoric acid showed effect against HL-60 and A2780, with IC50 values of 146.7 and 198.3 μg∙mL−1. This evidence concerns the gene TP53 and colon carcinoma.