Meta-analysis from 4 prospective observational studies in RA patients showed a pooled risk estimate for non-melanoma skin cancers in patients receiving TNF blockers of 1.33 (95%CI 1.06 to 1.60), with similar results observed in a meta-analysis of randomized controlled trials (RR 2.02, 95%CI 1.11 to 3.95) [5, 7]. Here, TNF is linked to rheumatoid arthritis.