HES1 and cancer: In the subgroup analysis stratified by cancer histological types, HES1 expression was also associated with both lung adenocarcinoma overall survival rate (pooled HR = 1.85, 95%CI: 1.31-2.60, p = 0.445 and I2 = 0.0%) (Fig. 6B) and lung squamous cell carcinoma overall survival rate (pooled HR = 1.85, 95%CI: 1.11-3.06, p = 0.921 and I2 = 0.0%) (Fig. 6C).