Moreover, greater possibility of lymph node metastasis (LNM) and higher tumor stages were linked with high Notch1 expression in NSCLC (pooled OR = 3.20, 95%CI: 1.81-5.65, p = 0.798 and I2 = 0.0%; pooled OR = 1.62, 95%CI: 1.00-2.62, p = 0.251 and I2 = 25.5%) (Fig. 2B,C). This evidence concerns the gene NOTCH1 and metastatic malignant neoplasm in the lymph nodes.