However, there was no statistical association between Notch1 expression and two main histological types of NSCLC: adenocarcinoma (ADC) and squamous cell carcinoma (SCC) (pooled OR = 0.96, 95%CI: 0.75-1.22, p = 0.068 and I2 = 42.1%) (Fig. 2D). This evidence concerns the gene NOTCH1 and non-small cell lung carcinoma.