In the present study, we found hOXR1-MSCs transfer into lupus nephritis mice inhibited macrophage and T lymphocyte infiltration into kidneys accompanied by the down-regulation of cytokines associated with cell infiltration, such as monocyte chemotactic protein-1 (MCP-1), CCL7/MCP-3, IL-1β, IL-2, IL-6 and IP-10. Here, IL1B is linked to lupus nephritis.