PRNP and Alzheimer disease: A small molecule inhibitor of the interaction of Aβ with PrP would be of obvious use in further investigation of the role of PrP in AD pathogenesis and the relative importance of other putative Aβ oligomer receptors, which now include leukocyte immunoglobulin-like receptor LilrB2 (32), EphB2 kinase (33), and immunoglobulin G Fcγ receptor II-b (FcγRIIb) (34).