We show that delivery of miR-511 to mice down-regulates TNFR1 protein and protects against TNF, as well as against endotoxic shock and lethal hepatitis, and that anti-miR-511 up-regulates TNFR1 and sensitizes for TNF, both in B and in S mice, breaking the resistance of S mice to TNF. Here, TNFRSF1A is linked to hepatitis A virus infection.