Interestingly, transient in vivo delivery of miR-511 down-regulated TNFR1 in livers of mice and protected them not only against TNF, but also against endotoxic shock (in a TNFR1-dependent way) and in a model of TNF-mediated lethal hepatitis (induced by ConA). This evidence concerns the gene TNFRSF1A and hepatitis A virus infection.