ACAN and metabolic syndrome: Thus far, there is limited evidence that ethnicity, metabolic syndrome, genetic components adduction moment, meniscal damage, knee ROM, general vitamin and β-carotene intake, serum levels IL-10 and N-propeptide of type II collagen, synovial levels aggrecan neoepitope amino acid sequence and IL-18, and fractal dimension progression on radiographic fractal signature analysis are associated with progression of knee OA.