These more objective approaches recurrently show that BARD1 belongs to the group of the most frequently mutated genes, after BRCA1 and BRCA2. For example, recent analysis of 1824 patients with triple-negative breast cancer unselected for family history led to the identification of 9 definitive BARD1 mutations (more mutations was identified only in BRCA1, BRCA2 and PALB2)29. Here, BRCA1 is linked to triple-negative breast carcinoma.