LEP and coronary artery disorder: Indeed, it is possible that our finding of an association between circulating leptin and risk for ischemic heart disease was statistically significant after correction for traditional risk factors in men and women was made possible by reasonably good control of glycaemia, blood pressure and cholesterol that increased the chance to detect the risk related leptin, that might act through other mechanisms than mediated by the traditional risk factors that are known to the provider of care.