Acute or ‘early’ responders were first identified in the study based on the time interval between arthritis induction and a sharp increase in CRP or clinical score defined by: (i) an acute phase response of CRP (>50 mg/L) between day 10 to 14, or (ii) a clinical score of five before day 24 [22, 26]. This evidence concerns the gene CRP and arthritic joint disease.