Accordingly, stably transfected VM-CUB1 HOTAIR clones showed a significantly increased expression of HOXD8 and HOXD9. However, 5637 clones stably overexpressing HOTAIR were the only instance of a decrease in HOXD10. Clearly, HOTAIR target genes in the HOXC and HOXD clusters differ between urothelial and breast carcinoma. The gene discussed is HOXD8; the disease is breast carcinoma.