Fat- and muscle-specific RNA interference (RNAi) knockdown of about 1,000 genes followed by glucose measurements uncover 161 unique hyperglycaemia hits, including 76 novel candidates, one of which, Ck1alpha, is tested for glucose regulatory role in mice; loss of one or two copies of the mammalian Ck1alpha homologue, CSNK1a1, in the adipose lineage results in hyperglycaemic mice. The gene discussed is CSNK1A1; the disease is Hyperglycemia.