Accordingly, we have identified known tumor suppressors (for example, TSG1, RBM6, SPRY2, CDKN1A, and UBE4B) in the set of genes potentially regulated by the hypermethylated enhancers and known oncogenes and cancer-associated genes (for example, MYC, TERT, ERBB3, ERBB4, FGFR3, VEGFA, CDK7, and CCND1) in the set of genes potentially regulated by the hypomethylated enhancers. Here, SPRY2 is linked to cancer.