We chose TLR2 ligands because it was reported that linc0949 and linc0597 were regulated in THP-1 macrophages following Pam3CSK4 stimulation [26] and TLR2 was required for the production of prototypical lupus autoantibodies and the development of renal disease in murine lupus [36,37]. The gene discussed is TLR2; the disease is systemic lupus erythematosus.