NSD3 and cancer: These potential alternative driver alterations were found to affect known cancer genes (Table 1), including amplification of PIK3CA or MYC, and likely driver genes mapping to the 8p11-p12 amplicon, including ZNF703 [33], RAB11FIP1 [28,29], LSM1 [28], PPAPDC1B [35], WHSC1L1 [28,41] and FGFR1 [40,46].