This list of genes contains numerous likely breast cancer drivers, including MDM4 [32], ZNF703 [33], RAB11FIP1 [28,29], MYC, FAM83A [34], PIK3CA, PROSC [28], PPAPDC1B [35], LSM1 [28,36], BAG4 [36], EEF1A2 [37], CAMK1D [38], PHGDH [39], FGFR1 [40], DDHD2 [28] and WHSC1L1 [28,41] (Additional file 5). The gene discussed is PIK3CA; the disease is breast carcinoma.