Regarding the analysis of internal organ complications, we report here the association of HLA-B*35:12 and HLA-DQB1*06:03 alleles to severe joint involvement; only the study by Tikly et al [41] had found an association of HLA-DQB1*06:03 to a SSc feature (the presence of anti-fibrillarin antibodies). Here, HLA-B is linked to systemic sclerosis.