B) We also found significant increase of the Caucasian HLA-C*07:01-B*08:01 block frequency (bf) in all SSc patients (bf 3.4%), as well as in both dcSSc (bf 3.9%) and lcSSc (bf 3.19%) groups, when compared to controls (bf 0.6%, SSc vs Ctls pC = 0.007, OR = 5.59, 95%CI = 1.54–20.2; dcSSc vs Ctls pC = 0.01, OR = 6.3, 95%CI = 1.48–26.73; lcSSc vs Ctls pC = 0.03, OR = 5.1, 95%CI = 1.26–20.65). The gene discussed is HLA-C; the disease is systemic sclerosis.