HLA-B and systemic sclerosis: The separate analysis of the alleles from this block showed increased frequency of HLA-B*08:01 in all SSc (gene frequency (gf) 4%), in dcSSc (gf = 4%) and in lcSSc (gf = 4.2%) patients when compared to controls (gf = 0.6%; SSc vs Ctls pC = 0.0008, OR = 7.1, 95%CI = 2.04–25.21; dcSSc vs Ctls pC = 0.003, OR = 7.6, 95%CI = 1.88–30.92; lcSSc vs Ctls pC = 0.003, OR = 6.8; 95%CI = 1.8–26.25).