The admixture estimations using HLA-B revealed a contribution of 53.6% of Amerindian, 28.5% of Caucasian and 17.1% of African genes in SSc patients whereas in Controls we found 59.97% of Amerindian, 25.7% of Caucasian, and 14.5% of African genes contribution. Here, HLA-B is linked to systemic sclerosis.