This study confirms the findings by Arnett et al [15], Gladman et al [16] and Loubiere et al [36] that have found this association previously, while Simeon et al [37] and Reveille et al [38] found association of this allele (HLA-DRB1*11:04) to anti-topoisomerase antibodies in SSc patients; this association probably includes the same type of patients because this autoantibody is the most frequent in dcSSc patients [2]. This evidence concerns the gene HLA-DRB1 and systemic sclerosis.