Arachidonic acid can be converted into prostaglandin E2 (PGE2)and other prostaglandins by cyclooxygenase-2 (COX2) [23], which plays a role in regulating the migratory and invasive behavior of cells during the development and progression of cancer [24].Additionally, COX-2 expression in osteosarcoma lung metastases can be used as a prognostic factor [25].Furthermore, LPA has been demonstrated to induce cell proliferation, invasion, migration and survival [7]. Here, PTGS2 is linked to osteosarcoma.