These brain-specific splices are likely of importance for neural biology as four of them: NEO1, KIF2A, APLP2, and MAP2 were shown to be alternatively spliced during neuronal differentiation of P19 mouse embryonal carcinoma cells [23] and the latter three ASEs were also shown to be targets of PTBP1, which is a key splicing factor that is down-regulated during neurogenesis [16,17]. The gene discussed is MAP2; the disease is embryonal carcinoma.