The treatment of arthritic rats with tropical liver fluke, Fasciola gigantica and the amphistome, Gigantocotyle explanatum derived somatic antigens resulted in significant remission of the disease as manifested by clinical symptoms (swelling, redness and restriction in movement), depletion in serum TNF-α and IFN-γ, increased serum IL-4 and IL-10 levels, under expression of MMPs, decline in NO synthesis and amelioration of patellae pathology. This evidence concerns the gene TNF and medical procedure.