IFNG and rheumatoid arthritis: The skewing of pro-inflammatory response towards an anti-inflammatory nature and thereby suppression of MMPs, could be a valid therapeutic strategy in RA and that could be achieved by the use of helminth antigens because it has been revealed that ES62 antigen derived from a filarial nematode suppresses TNF-α and IFN-γ in Collagen-induced arthritis [32].