They found relatively small quantitative differences in markers expression when comparing NSCLC with asthma patients, and propose a four or five-marker panel for diagnosis excluding the asthma category, with sensitivity and specificity in the four best subset of markers of 93 and 87% (composed of EGF, sCD40 ligand, Interleukin 8 and Matrix Metalloproteinase-8). Here, MMP8 is linked to non-small cell lung carcinoma.