TFPI and susceptibility to pneumonia measurement: For instance, in a murine model of ongoing pneumonia, delayed rh-TFPI treatment inhibited accumulation of neutrophils in lung tissue and reduced cytokine and chemokine levels, suggesting that TF-mediated coagulation might only influence inflammation during an ongoing procoagulant/proinflammatory response, and this effect became only apparent without concurrent antibiotic treatment [13].