To evaluate how KRAS-driven NSCLC cells are regulated by the HER receptors, we performed short hairpin (shRNA) -mediated knockdown of EGFR, HER2 and HER3 on two candidate cell lines from the EGFR/HER dependent (H358) and EGFR/HER independent (A549) groups (as evaluated in Fig. 2). The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.