By taking advantage of the presence of 425 DCIS cases in the Curtis dataset (Oncomine), our analysis revealed a significant increase of SIPL1 mRNA in DCIS in comparison to normal breast tissue and that the SIPL1 mRNA levels remained high in invasive carcinoma (Fig 8), suggesting a critical role of SIPL1 in early stages of cancer formation. Here, SHARPIN is linked to cancer.