TNF and breast cancer: In contrast, and in agreement with the established phenotype of reprogrammed monocytes as well as our cytokine and flow cytometry data (Fig 1E, S5 and S6B Figs), the expression of the pro-inflammatory cytokines TNF and IL-1β, as well as HLA-DR and CD86 was significantly higher in the healthy controls when compared to breast cancer/sepsis patients (Fig 4B) [25].