CYP3A5 and acute myeloid leukemia: The associations of genetic susceptibility with EAL risk stratified according to MLL status were also tested, but only the heterozygous genotype of CYP3A5 presented a significant increase of AML risk in MLL-GL cases (aOR = 2.21; 95% CI, 1.12–4.35), though the significance did not remain after multiple testing adjustment (S7 Table).