An understanding of how Nrg1 expression and neurobiological function are changed in Nrg1 TM HET mice is critical to determine which aspects of the Nrg1-related molecular and cellular changes found in schizophrenia may be recapitulated in this mouse, and to better model the relationships between Nrg1 alterations and pathophysiological/behavioural outcomes. This evidence concerns the gene NRG1 and schizophrenia.