Based on these findings, it can be hypothesised that species that correlate with changes in body weight and leptin, such as Lactobacillus intestinalis or Bacteroides fragilis, are more likely to be indirectly involved in increases in adiposity, while those correlating with plasma insulin level, GTT/ITT responses, such as the Clostridiaceae family, might be more associated with an insulin-resistance/glucose intolerance phenotype. The gene discussed is LEP; the disease is Insulin resistance.