In thecurrent study, the activation of SIRT1 by resveratrol reversed the increase ofTNF-α and IL-1β levels in lung tissues from rats with burn-inducedALI (Fig. 2D-E), indicating that resveratrol could attenuateburn-induced lung injury by decreasing TNF-α and IL-1β expression.This result was further confirmed by the improvement on neutrophil infiltration,interstitial edema, and pulmonary hemorrhage in the lung after resveratroladministration as shown in Fig. 2A. The gene discussed is TNF; the disease is Pulmonary hemorrhage.