In order to directly test whether the central-memory phenotype CCR7 + CD62L + CD8+ TILs in tumor-immune mice mediated resistance to subsequent tumor inoculation, we depleted CD8 T cells at day 80 after primary tumor control in α-CTLA-4/α-PD-L1 mAb treated mice with 2.43 hybidoma purified antibodies, followed by re-challenge with additional K7M2 tumor cells. Here, CTLA4 is linked to neoplasm.