BCHE and early-onset autosomal dominant Alzheimer disease: It has been more than two decades since the first cholinesterase inhibitor (ChEI) was approved for Alzheimer’s disease (AD) dementia and more than a decade since an agent from a distinct pharmacological class of treatment —memantine, the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist [1]— was approved.