INS and type 2 diabetes mellitus: In a randomized cross-over clinical trial of type 2 diabetic patients, acute intra-femoral infusion of sodium nitroprusside (a NO donor compound) compared to verapamil, resulted in greater glucose uptake independent of plasma insulin concentration [46], but infusion of sodium nitroprusside or oral supplementation with nitrate (as isosorbide mononitrate or pentaerythritol tetranitrate) in healthy men had no effect on plasma glucose or insulin levels [49].