2004; Young et al. 2012). The present results would suggest that in mice the MR – ENaC – EO pathway is important for salt/CSF [Na+]-induced hypertension but not for Ang II-induced hypertension as neither an increase in plasma membrane ENaC nor blockade of EO actions by the  affected the Ang II-induced hypertension. The gene discussed is AGT; the disease is hypertensive disorder.