2012), the absence of pressor responses to CSF[Na+] in /Nedd4-2−/− mice (present study), and the prevention of most of the salt-induced hypertension in Nedd4-2−/− mice by central infusion of benzamil (Van Huysse et al. 2012), inhibition of the α2-isoform by EO in glia in the CNS appears to play a critical role. The gene discussed is NEDD4L; the disease is hypertensive disorder.