Using in house Glioblastoma Bio Discovery Portal (GBM-BioDP-(http://gbm-biodp.nci.nih.gov)) [29], multivariate cox proportional hazards model survival analysis was carried out examining miR-21, PDCD4 and MSH2 expression (red- above median expression, blue- below median expression) and overall survival association in different subclasses (C-classical, M-mesenchymal, P- proneural and N- neural) of GBM (197 patients), along with their expression profile as Box plots (Figure S4). This evidence concerns the gene MSH2 and glioblastoma.