WEE1 and glioblastoma: Previously, we performed a siRNA-based RNAi screen focused on the human kinome to identify protein kinases required for the survival of GBM [4] and identified Monopolar spindle 1 (MPS1 also known as TTK) as a putative target for GBM therapy and demonstrated MPS1 inhibition radiosensitizes GBM cells by abrogating DNA repair and as a consequence, cells eventually undergoing mitotic catastrophe [5].