Consistent with our hypothesis ectopic expression of miR-21 mimics after MPS1 inhibition (siMPS1 (lane 6, Figure 4A, 4C) or NMSP715 (lane 4, Figure 4B, 4D)) significantly (P < 0.05) but not totally rescued GBM cell attenuation. This evidence concerns the gene TTK and glioblastoma.