19 have shown that upon long-term infusion of AngII in mice, the number of peripheral blood T lymphocytes was increased. Kvakan et al. 20 observed a beneficial role of naturally occurring T regulatory cells after adoptive transfer into AngII-induced inflamed mice exhibiting cardiac damage. Additionally, the preventive role of post-MI activated AT2R-expressing CD8+ T cells secreting interleukin-10 (IL-10) has been reported by our group with the exception that only post-MI activated AT2R-expressing CD8+ T cells, which secreted IL-10 reduced the infarction size in MI recipient rats 18. The gene discussed is CD8A; the disease is myocardial infarction.