ANRIL associates with PRCs PRC1 and PRC2 through chromodomain proteins CBX7 and SUZ12 to repress the prosenescence INK4 locus in prostate cancer cells and proliferating primary fibroblasts, thus suggesting an antisenescence function for the complex (Fig. 3a and Table 1). The gene discussed is CDKN2B-AS1; the disease is prostate cancer.