The hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) is an autoinflammatory disease characterized by recurrent episodes of fever, cervical lymphadenopathy, hepatomegaly, splenomegaly, abdominal pain, skin rash, arthralgia, and other inflammatory symptoms [1] accompanied by increased inflammatory markers such as C-reactive protein (CRP) and serum amyloid A (SAA). Here, CRP is linked to periodic fever syndrome.