Cytokine secretion after HPV16 E2 and E6 stimulation is summarized in the Figure 3 A and B. As only one woman (ID13) had HPV16 E7 specific LST response, the HPV16 E7 data was excluded from the Figure 3 A and B. In the CIN women, IL-10 was the most frequently secreted cytokine, being detected in all 10 women, followed by IL-17A and IFN-γ, with 90% (9/10), and by IL-2 and IL-5, secreted in 80% (8/10) of the women. This evidence concerns the gene IL2 and cervical squamous intraepithelial neoplasia.