When only including samples closer to disease onset in the analyses (when the frequencies of the different antibodies started to increase, ≤10.5 years prior to symptom onset of RA, n = 288 individuals), the presence of antibodies against CCP2, CEP-1/Eno5-21, citC1359-369, Fibβ62-81b, Fibβ36-52, and CCP-1/Fil307-324 were all significantly associated with the combination of HLA-SE and ever-smoking (Table 2). Here, AGBL2 is linked to rheumatoid arthritis.