The combination of three (CEP-1/Eno5-21, Fibß36-52, and CCP-1/Fil307-324) or four (CCP2, CEP-1/Eno5-21, Fibß36-52, and CCP-1/Fil307-324) of the most frequently occurring antibodies being positive together with smoking and HLA-SE resulted in even higher ORs for development of RA among the pre-symptomatic individuals (OR = 61.03, 95% CI: 13.95 to 267.05), compared with being negative for any of the antibodies (Table 4). Here, AGBL2 is linked to rheumatoid arthritis.